My grandmother is too old to look after now.

A. himself B. herself

C. myself D. yourself

B 【解析】句意：我祖母太老了，不能照顧自己了。A. himself反身代詞，他自己；B. herself反身代詞，她自己；C. myself 反身代詞，我自己；D. yourself反身代詞，你（們）自己。本句指“my grandmother”，女性，“她自己”。故選：B。
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