It is uncertain    side effect the medicine will bring about, although about two thousand patients have taken it．
A．thatB．whatC．howD．whether
B

試題分析：句意：盡管大約2000名病人使用了這種藥，但它會帶來什么樣的副作用還不清楚。這里是賓語從句，賓語從句中 bring about后缺少賓語，此處what修飾名詞side effect。故選B。
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