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A serious illness, ______ its nature, is almost always painful.
A．whateverB．whereverC．wheneverD．however
A

試題分析：考察讓步狀語從句，本句在nature后面省略了is。Whatever引導起這個讓步狀語從句，并在句中作為is 的表語。BCD三項都是副詞，通常不能在句中作表語。句意：無論是什么樣的性質，一種嚴重的疾病總是會讓人痛苦。故A正確。
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