Have you noticed the problem ___ he is now in low spirit ? ____ come?
A．where, What B．that, HowC．in which, ForD．what, As
B
that引導(dǎo)同位語(yǔ)從句，是problem的內(nèi)容。后面的how come 意思是“怎么會(huì)那樣？”符合上下文的意思。
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