his knowledge of the mountainous village, John was appointed as our guide.

A. In spite of B. On account of

C. Regardless of D. Instead of

B

【解析】

試題分析：考查介詞短語的辨析。In spite of雖然，盡管…；On account of考慮到，基于，由于；Regardless of不管，不顧；Instead of代替，而不是。句意：考慮到他對鄉(xiāng)村知識的了解，John被任命為我們的向?qū)�。故選B。

考點(diǎn)：考查介詞短語的辨析

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